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Huntingtin Polyclonal Antibody

Catalog No.:AB0080-200

Price / Unit: EUR 320.00

Source: Goat

Quantity/unit size: 600 µg

Description: Huntingtin is a protein linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons.

Alternative names: HD, HTT and IT15 antibody.

Form: Polyclonal antibody supplied as a 200 µl (3 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum.

Immunogen: Purified recombinant peptide derived from within residues 85 to 200 aa of human HTT produced in E. coli.

Specificity: Reacts huntingtin protein, amino acids 85-200. The antibody recognizes wild type and mutant huntingtin.

Reactivity: Reacts against human, rat and mouse proteins.

Usage: Western blot                       1:500-1:2,000
Immunofluorescence                       1:500-1:2,000
Immunohistochemistry (paraffin)     1:500-1:2,000
Immunohistochemistry (frozen)       1:500-1:2,000

Reactivity chart

Sample Western Blot Immuno-fluorescence Immuno-Histochemistry (p) Immuno-Histochemistry (f)
human +++ +++ +++ +++
rat +++ +++ +++ +++
mouse +++ +++ +++ +++
canine +++ +++ +++ +++
monkey +++ +++ +++ +++

Storage: Store at -20 C for long term storage. Store at 2-8 C for up to one month.

Special instructions: Avoid freeze/thaw cycles.

References

1. Miniarikova J, Zimmer V, Martier R, et al. Gene Ther. 2017 Oct. PMID:28771234
2. Meunier C, Merienne N, Jollé C, et al. Glia. 2016 Jul 21. PMID: 27442486
2. Déglon N, Merienne N, Genome editing for the treatment of huntington's disease, EP 2982758 A1 Patent, 2014



For research use only, not for diagnostic use