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E-Cadherin Polyclonal Antibody

Catalog No.:AB0057-200

Price / Unit: EUR 300.00

Source: Goat

Quantity/unit size: 400 µg

Description: Goat polyclonal to CDH1. CDH1 is a classical member of the cadherin superfamily. This protein is a calcium dependent cell-cell adhesion glycoprotein comprised consists of 5 cadherin repeats in the extracellular domain, one transmembrane domain, and a and a highly conserved intracellular domain that binds b-catenin and p120-catenin. CDH1 is involved in mechanisms regulating proliferation, mobility and cell-cell adhesions of epithelial cells. Loss of E-cadherin function or expression has been implicated in cancer metastasis and progression.

Alternative names: ARC-1, CAM 120/80, CD324, CDH1, cdhc-A, CDHE, ECAD, E-Cad E-cadherin, Epithelial cadherin, l-cam, LCAM, P09803, P12830 / Q9R0T4, UVO, Uvomorulin, XBcad, XB-cadherin, XTCAD-1 antibody.

Form: Polyclonal antibody supplied as a 200 µl (2 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum.

Immunogen: Recombinant peptide derived from within residues 750 to 850 of human CDH1 produced in E. coli.

Specificity: Detects endogenous levels of total E-cadherin protein by Western blot in the whole cell lysates (COS-7 and MDCK).

Reactivity: Reacts against human, rat, mouse, canine and monkey proteins.

Usage: Western blot                            1:500-1:2,000
Immunofluorescence                                    ND
Immunohistochemistry (paraffin)                  ND
Immunohistochemistry (frozen)                    ND

Reactivity chart

Sample Western Blot Immuno-fluorescence Immuno-Histochemistry (p) Immuno-Histochemistry (f)
human +++ ND ND ND
mouse +++ ND ND ND
rat +++ ND ND ND
monkey +++ ND ND ND
canine +++ ND ND ND

Storage: Store at -20 C for long-term storage. Store at 2-8 C for up to one month.

Special instructions: Avoid freeze/thaw cycles.

References




For research use only, not for diagnostic use