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Connexin 43 Polyclonal Antibody

Catalog No.:AB1600-500

Price / Unit: EUR 450.00

Source: Goat

Quantity/unit size: 2 mg

Description: Goat polyclonal to connexin 43, which is a member of the connexin family. Cx43 is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. This protein is the major protein of gap junctions in embryonic development and in the heart that are thought to have a crucial role in the synchronized contraction of the heart.

Alternative names: AVSD3, CX43, DFNB38, gap junction protein, alpha 1, 43kDa, GJA1, GJAL HSS, HLHS1, ODDD antibody.

Form: Polyclonal antibody supplied as a 500 µl (4 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum and it is identical to AB0016-500.

Immunogen: Purified recombinant peptide derived from within residues 230 aa to the C-terminus of rat CX43 produced in E. coli.

Specificity: Detects endogenous levels of total connexin 43.

Reactivity: Reacts against human, rat, mouse, canine and monkey proteins.

Usage: Western blot                           1:500-1:2,000
Immunofluorescence                             1:50-1:250
Immunohistochemistry (parafin)          1:250-1:800
Immunohistochemistry (frozen)           1:250-1:800

Reactivity chart

Sample Western Blot Immuno-fluorescence Immuno-Histochemistry (p) Immuno-Histochemistry (f)
human +++ +++ +++ +++
rat +++ +++ +++ +++
mouse +++ +++ +++ +++
canine +++ +++ +++ +++
monkey +++ +++ +++ +++

Storage: Store at -20 C for long term storage. Store at 2-8 C for up to one month.

Special instructions: Avoid freeze/thaw cycles.

References

1. Martins-Marques T, Pinho MJ, Zuzarte M. et al. J Extracell Vesicles. 2016 Sep 29;5:32538. PMID:27702427
2.Martins-Marques T, Anjo SI, Pereira P, et al. Mol Cell Proteomics. 2015 Aug 27. PMID:26316108 Supplemental Information
3. Ribeiro-Rodrigues TM, Catarino S, Marques C, et al. FASEB J. 2014 Nov;28(11):4629-41. PMID:25070368



For research use only, not for diagnostic use