Cathepsin D Polyclonal Antibody
Catalog No.:AB0043-200
Price / Unit: EUR 320.00
Source: Goat
Quantity/unit size: 600 µg
Description: Goat polyclonal antibody to Cathepsin D. Cathepsin D is a lysosomal aspartic protease of the pepsin family. Acid protease active in intracellular protein breakdown. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Alternative names: ceroid-lipofuscinosis, CLN10; CPSD, CTSD, lysosomal aspartyl protease, lysosomal aspartyl peptidase, neuronal 10 antibody.
Form: Polyclonal antibody supplied as a 200 µl (3 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum.
Immunogen: Purified recombinant peptide derived from within residues 275 aa to the C-terminus of human Cathepsin D produced in E. coli.
Specificity: This antibody gives a positive signal in the following human (Jurkat, HT1080, HUH, MDA-MB-231, ARPE19, SH-SY5Y), canine (MDCK) and monkey (COS-7) whole cell lysates.
Reactivity: Reacts against human, rat, mouse, canine and monkey proteins.
Usage: Western blot 1:250-1:1,000
Immunofluorescence 1:50-1:200
Immunohistochemistry (paraffin) 1:50-1:200
Immunohistochemistry (frozen) 1:50-1:200
IEM 1:50-1:200
Reactivity chart
| Sample | Western Blot | Immuno-fluorescence | Immuno-Histochemistry (p) | Immuno-Histochemistry (f) | human | +++ | +++ | +++ | +++ | rat | +++ | +++ | +++ | +++ | mouse | +++ | +++ | +++ | +++ | canine | +++ | +++ | +++ | +++ | monkey | +++ | +++ | +++ | +++ |
|---|
Storage: Store at -20 C for long term storage. Store at 2-8 C for up to one month.
Special instructions: Avoid freeze/thaw cycles.
References
1. Romagnoli M, Bresson L, Di-Cicco A, et al. Development 2020 Jan. PMID:31988184
2. Pelkonen L, Sato K, Reinisalo M, et al. Mol Pharm 2017 Mar. PMID:28112518
For research use only, not for diagnostic use
